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Effect of MK-801 on DNA fragmentation induced by CsA treatment in mixed neuronal-glial cultures. Cyclosporin A was added 6 days after plating of cells. DNA fragmentation was detected using TUNEL method at 24 h after treatment in cells maintained under various conditions: in untreated cultures (A), cultures exposed to 1 μM MK-801 (B) or 8 μM CsA (C) alone, and MK-801 and CsA (D).
