Figure 1.
Effects of Aβ1–42 on nitrite production in primary cortical mixed cell cultures. At 5, 10, and 20 μM, Aβ1–42 significantly increased nitrite production as compared to control (no Aβ peptide exposure). The reverse peptide Aβ42–1 (10 and 20 μM) did not increase nitrite production significantly in the cultured cells. Data represent mean±s.e.mean of 6–9 wells from seven independent experiments. One-way ANOVA with Bonferroni's multiple comparison test and Student t-test were used to analyse statistical significance. *P<001; **P<0.001.