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Effect of kinin antagonists on thermic oedema. Plasma extravasation in the ears of wildtype mice pretreated (−5 min; i.v) with vehicle control, des-Arg10 Hoe 140 (1 μmol kg−1) or Hoe 140 (100 nmol kg−1) at (A) 10 min, (B) 30 min and (C) 60 min post-burn (55°C). All data are presented as mean±s.e.mean. ***P<0.001 vs control in the same animal at the same time point, +++P<0.001 vs burn in animals treated with vehicle; n=5.
