Figure 3.

Saturation-binding analysis of [³H]-paroxetine to the cortex of saline and fluoxetine injected rats 2 (a), 4 (b) and 7 (c) days after treatment. Rats received two doses of fluoxetine (10 mg kg⁻¹, i.p.) with an interval of 60 min. A saturation isotherm obtained from 4 – 8 experiments per group in triplicate is shown. B_max and K_D of cortical [³H]-paroxetine binding in saline- and fluoxetine-treated rats is shown as mean±s.e.mean. The data were best fitted to a single site model (r²=0.99). Different from saline: *P<0.05, **P<0.01, ***P<0.001.