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. 2001 Sep;134(1):46–57. doi: 10.1038/sj.bjp.0704230

Figure 6.

Figure 6

Effect of fluoxetine or fluvoxamine on the 3,4-methylenedioxymethamphetamine (MDMA)-induced hyperthermia. (a) Rectal temperature of rats injected with fluoxetine (10 mg kg−1, i.p., two doses, 60 min apart) or saline 4 days before MDMA (15 mg kg−1, i.p.) or 5 min before and 55 min after MDMA. Arrow indicates MDMA injection. MDMA significantly increased temperature compared to saline treatment (F(1,21)=116.4; P<0.001). Fluoxetine either co-administered with MDMA or injected 4 days before did not modify the hyperthermic response (F(1,13)=0.283 and F(1,15)=2.61, respectively). (b) Rectal temperature of rats injected with fluvoxamine (15 mg kg−1, i.p.) or saline 5 min before and 55 min after MDMA. MDMA significantly increased temperature compared to saline treatment (F(1,10)=133.1; P<0.001). Co-administration of fluvoxamine with MDMA did not modify the hyperthermic response (F(1,10)=0.409). Results shown as mean and vertical lines indicate s.e.mean (n=6 – 12).