Figure 4.
Effects of SCH 58261 or imipramine in the tail suspension test performed in a genetic mouse model of depression. Outbred CD1 mice were used as the foundation population of a line of mice that was selectively bred for its high spontaneous helplessness (immobility scores ⩾115 s=helpless) in the tail suspension test. Mice of both sexes (7th generation) were injected with SCH 58261 10 mg kg−1 i.p. (right panel) or imipramine 30 mg kg−1 i.p. (left panel) 30 min before the test. Testing was for 6 min. Means±s.e.mean. of data from 18 – 22 in each group. ***P<0.001 (one-way ANOVA followed by Student-Newman-Keuls test) as compared to vehicle-injected groups.