Figure 6.

Effects of haloperidol on stimulation of locomotor activity and anti-immobility response induced by SCH 58261. Mice were injected with saline (open bars) or increasing doses of haloperidol (50, 100, 200 μg kg⁻¹ i.p.) (hatched bars). Fifteen minutes later, they were injected with vehicle or SCH 58261 (10 mg kg⁻¹ i.p.). Upper panel – locomotor activity test – Immediately after the second treatment, mice were introduced into the actimeters. The horizontal activity was measured for 45 min. Means±s.e.mean. of data from 8 mice per group. Two-way ANOVAs: (interaction of haloperidol×SCH 58261): F(2,47)=4.11, P=0.02. Lower panel – forced swim test – mice pretreated with haloperidol or saline received vehicle or SCH 58261 30 min before testing. The duration of immobility was recorded during the last 3-min of the 6-min testing period. Means±s.e.mean of data from 14 controls and 8 – 11 mice in treated groups. Two-way ANOVAs: (interaction of haloperidol×SCH 58261): F(3,72)=5.04, P<0.01. Post hoc comparisons: ^**P<0.01, ^***P<0.001 as compared with respective SCH 58261 untreated control groups; ##P<0;01; ###P<0.001 as compared with respective haloperidol-untreated control groups.