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Effect of HS-599, buprenorphine and morphine on conditioned place-preference test in rats. Results are presented as mean±s.e.mean of time (seconds) that rats spent in the drug paired compartment before (control) and after the acquisition of conditioned place-preference (n=6 per group). Results were analysed by a paired two-tailed t-test. All HS-599 values P⩾0.0680 (not significant); buprenorphine, **P=0.0021; morphine, ***P=0.0003.
