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Antagonism by naloxone (NLX, 3 mg kg−1 s.c.), naltrexone (NLTX, 10 mg kg−1 s.c.), naltrindole (NTI, 20 mg kg−1 s.c.) and nor-Binaltorphimine (nor-BNI, 20 mg kg−1 s.c.) of the antinociception induced by HS-599 (0.2 μmol kg−1 s.c.), in rats (tail-flick test). Each column represents the mean±s.e.mean for 5 – 8 rats in each group. **P<0.01 versus the vehicle-pretreated group.
