Figure 3.

Effects of Dan and GIF-0082 on caffeine- and clofibric acid-induced Ca²⁺ release in skinned fibres. The rates of Ca²⁺ release with 20 μM Dan or 50 μM GIF-0082 were measured under Mg²⁺- and Ca²⁺-free conditions (buffered with 10 mM EGTA) with 5 – 20 mM clofibric acid (Clof, Figure 3a, mean±s.e.mean, n=3 – 6) or with or without CICR activators (caffeine, Caf; AMP; Figure 3b, n=5 – 7). Note the difference in the scales. (c) The results in a and b were normalized to the control value (without Dan or GIF-0082) within each preparation. ^*P<0.05, ^**P<0.01, ^***P<0.001.