Figure 5.

Effects of some Dan derivatives on Ca²⁺ release. (a) The sizes of twitch contraction after treatment of GIF-0146, GIF-0149-R, GIF-0163, or GIF-0185 (50 μM) were compared with those before treatment in intact muscle. (b) In skinned fibres, the rates of Ca²⁺ release measured with these derivatives at pCa 6.0 in the absence of Mg²⁺ were normalized to the control value (without the derivatives) within each preparation (mean±s.e.mean, n=3 – 4 for a, n=3 for b).