Figure 1.

Experimental protocols illustrating the times and routes of antiserum and drug adminstration. i.c.v.=intracerebroventicularly; i.p.=intraperitoneally; s.c. subcutaneously. pAb=anti-annexin 1 polyclonal antiserum (3 μl rat⁻¹ i.c.v. or 1 ml kg⁻¹, s.c); NSS=non-immune sheep serum (3 μl rat⁻¹, i.c.v. or 1 ml kg⁻¹, s.c); Cort=corticosterone (500 μg kg⁻¹, i.p. in a volume of 1 ml kg⁻¹); IL-1β=interleukin 1β (10 ng rat⁻¹ in a volume of 3 μl, i.c.v. or 500 μg kg⁻¹, i.p. in a volume of 1 ml kg⁻¹); ANX-1=annexin 1_{Ac2 – 26} (0.1 – 10 ng rat⁻¹ in a volume of 3 μl, i.c.v.). Corresponding volumes of saline (Sal) or vehicle (Veh) were administered as controls where appropriate.