Figure 3.

Effects of hexamethonium (HEX), atropine (ATR) and the combination of both (HEX+ATR) in normal and calcium-free buffer (0 Ca²⁺) on electrically evoked adrenaline release in rabbit isolated adrenal glands. Adrenaline release was elicited by trains of 2, 5 and 10 electrical pulses at 2 Hz. After an initial PRE-period, HEX (100 μM), ATR (0.5 μM) or HEX+ATR (same concentrations) were added to the superfusion medium. In one further group, HEX+ATR were superfused in calcium-free buffer. Effects of the drugs on electrically evoked adrenaline release were evaluated 30 min after the beginning of drug superfusion. Values are given as percentages of PRE. Means±s.e.mean from six (HEX), six (ATR), six (HEX+ATR) and six (HEX+ATR/0 Ca²⁺) experiments. Differences versus PRE: *P<0.05.