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. 2001 Nov;134(6):1319–1327. doi: 10.1038/sj.bjp.0704359

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Copyright 2001, Nature Publishing Group

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Effects of WIN55212-2 (WIN-2) on electrically evoked adrenaline release in rabbit isolated adrenal glands. Adrenaline release was elicited by trains of 2, 5 and 10 electrical pulses at 2 Hz as indicated by the arrows. After an initial PRE-period, increasing concentrations of WIN-2 (0.3, 1, 3 and 10 μM) were added to the superfusion medium. In two further experiments, WIN-2 was superfused in the presence of SR141716A (SR; 1 μM) or hexamethonium (HEX; 100 μM) plus atropine (ATR; 0.5 μM). Left panels show the electrically evoked adrenaline release before application of WIN-2. Right panels show the electrically evoked adrenaline release after 30 min of superfusion of WIN-2 10 μM. The vertical bar denotes the height of the oxidation current produced by superfusion of a 3 μM-adrenaline solution. Original tracings representing seven (WIN-2), six (SR+WIN-2) and five (HEX+ATR+WIN-2) experiments with similar results.