Figure 9.

Time-dependency of Taxol®-induced effects on viscosity and RBC morphology and missing reversibility after wash-out. Taxol® (corresponding to 100 μM paclitaxel) was incubated with whole blood (haematocrit 45%) at 37°C, and whole blood viscosity at high (A) and low (B) shear rate as well as RBC morphology (C), were determined at two consecutive time points (2 min and 60 min). Afterwards, RBCs were washed with PBS, resuspended in autologous plasma, and measurements were repeated at 37°C. n=6. ^*P=0.01 and ^**P=0.001 compared to control.