Figure 7.
Effects of cimetidine and indomethacin on pouch fluid volume, total number of leucocytes infiltrating into the pouch fluid and granulation tissue weight 6 days after carrageenin injection. Four milliliters of a 2% (w v−1) carrageenin solution in saline was injected into the air pouch. Five-hundred microliters saline containing 400 μg cimetidine, 100 μg indomethacin or both was injected into the pouch every day after the injection of carrageenin. Control rats received the same amount of saline. Pouch fluid volume (a), total number of leucocytes in the pouch fluid (b), and granulation tissue weight (c) were determined 6 days after injection of the carrageenin solution. Number of infiltrating eosinophils was too small to depict. Values are the means from five rats with s.e.mean shown by vertical bars. Statistical significance: *P<0.05, **P<0.01 and ***P<0.001 versus the corresponding control, and †P<0.05 and ††P<0.01 versus indomethacin (100 μg).