Figure 5.

Relative thromboxane receptor densities determined autoradiographically in (A) human non-diseased saphenous vein and saphenous vein grafts. (B) human non-diseased and atherosclerotic coronary artery. In saphenous vein grafts, the thromboxane receptor density in both the media and intima were significantly increased, compared to non-diseased saphenous veins of the corresponding smooth muscle cell layer. Compared to non-diseased coronary artery, TP receptor density was significantly increased in human atherosclerotic coronary artery, on both the media and intimal smooth muscle layer. In diseased vessels significantly fewer thromboxane receptors were localised to the intimal layer, compared to the medial smooth muscle layer. *P<0.05 Student's unpaired t-test, compared to non-diseased from respective smooth muscle layer. Values represent mean±s.e.mean (n=8 – 12 individuals).