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. 2002 Jan;135(1):143–154. doi: 10.1038/sj.bjp.0704440

Figure 4.

Figure 4

Endothelium-dependent relaxation in response to acetylcholine (ACh) in female (A) and male mice (B). In addition, endothelium-dependent relaxation to ATP (C) and endothelium-independent relaxation to SNP (D) were tested in aortae from female L2 and L2LPL mice. In the presence of 10 μM indomethacin the tissue was precontracted with 1 μM PE to achieve a stable contraction. A cumulative concentration response curve was conducted using ACh (female: n=8 each group; male: L2, n=6 and L2LPL, n=7), ATP (n=14 each group) and SNP (L2, n=9; L2LPL, n=7). Blood vessel relaxation is indicated as the reduction in tone in ‘g' achieved by the concentration of the agonist indicated (A,C) and as % relaxation (B,D). Each point represents the mean±s.e.mean. *P<0.05 vs relaxation obtained in aortae of the non-transgenic littermates (L2).