Steady-state tissue 125I-Ang I, 125I-Ang II, Ang I and II levels in femoral artery rings incubated with 125I-Ang I (100,000 c.p.m.) or Ang I (10 or 100 pmol) (left panels) or with 125I-Ang II (100,000 c.p.m.) or Ang II (10 pmol) (right panels) in the absence or presence of 1 μM irbesartan or 1 μM PD123319. Data are expressed as a percentage of the radiolabelled and endogenous Ang I or II levels in incubation fluid at t=0 (mean±s.e.mean, n=4 – 6).