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Concentration-response curve for LASSBio 294 in endothelium-intact rat aorta precontracted with noradrenaline. LASSBio 294 or its solvent DMSO (0.01 – 0.3%) were added at the plateau of the contraction induced by 1 μM noradrenaline (Nor) and left for 10 min to achieve a maximal effect. Curves were fitted by non-linear regression analysis using the one-site competition equation. Top and bottom were fixed at 100 and 0, respectively. P<0.05 (n=8).
