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Effect of L-NAME and indomethacin on LASSBio 294-induced vasorelaxant effect. The effect of LASSBio 294 was observed before and after the incubation of intact aortic rings with L-NAME (A) or indomethacin (Indo) (B) for 30 min. The contraction was induced by 0.3 or 3 μM noradrenaline (Nor), respectively. LASSBio 294 (LB-294) or DMSO were then added at the plateau and left for 10 min. *P<0.001 in relation to DMSO (n=7 – 9).
