Figure 5.

Effects of uraemic toxins on cellular proliferation of hOAT1-transformed OK cells. The hOAT1-transformed cells (closed circles) or vector-transformed control cells (open circles) were incubated in a culture medium containing 2.5% FBS and indicated concentrations of uraemic toxins for 24 h. Then, the cell number in each well was estimated by a cell counting kit. Values are mean±s.d. (n=4 to 8). (A), indoxyl sulphate. (B) indoleacetic acid. (C) Hippuric acid. (D) p-hydroxyhippuric acid. (E) o-hydroxyhippuric acid. *P<0.05 vs vector-transformed cells. †P<0.05 vs non-treated control.