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Effects of uraemic toxins with low and no affinity for hOAT1 on cellular free radical production of OK cells. The hOAT1-transformed cells (closed columns) or vector-transformed control cells (open columns) were incubated in Dulbecco's PBS containing 5 mM D-glucose, 20 μM dihydrofluorescein diacetate and indicated amount of uraemic toxins for 60 min at 37°C, and fluorescence intensities were measured. Values are mean±s.d. (n=4). †P<0.05 vs non-treated control.
