Figure 7.

The inhibition of spontaneous phasic activity of the pig bladder by K_ATP channel openers. (A) Concentration response curve for the K_ATP channel opener, P1075 and its reversal by glyburide. Shown is a representative tracing. (B) Mean concentration response curves for P1075 (n=8) and DMSO (n=8). Data were analysed as a percentage of maximum response. (C) The overall inhibition caused by P1075 (30 nM) expressed as a percentage change from baseline was due to a reduction in frequency with no substantial change in duration or amplitude. ^*Represents significant differences from baseline responses (P<0.05; n=4).