Figure 1.

Pressure – volume loops from an example control and heart failure dog demonstrating minimal influence of HMR 1098 on either basal (A,C) or epinephrine-stimulated (B,D) cardiac function. The baseline end-systolic pressure – dimension relation(s) is shown at the upper left of each plot, and indexes chamber contractile function. The solid line relates to the loop which is in the presence of HMR 1098. Dashed lines depict the relevant comparison data (either with or without epinephrine). Lastly, in the right panels, the pre-epinephrine relations are shown (baseline) to assist in comparison.