Figure 5.

Effect of selective COX inhibitors on the renal response to furosemide in rats with cirrhosis and ascites. Animals received i.v. placebo (n=6), the selective COX-1 inhibitor (SC-560, 20 mg kg⁻¹, n=10) or the selective COX-2 inhibitor (celecoxib, 20 mg kg⁻¹, n=10) and 1 h later they were challenged with an i.v. injection of furosemide (5 mg kg⁻¹) (time 0 min). Changes in urine flow (V) and urinary sodium excretion (U_NaV) were recorded for four 20-min urine collection periods after the injection of furosemide. Results are given as mean±s.e.m. Data are compared by the Student's t-test for unpaired data. *P<0.05; **P<0.025 and ***P<0.005 vs placebo-treated group.