Cumulative concentration-response curves for noradrenaline in the thoracic aortic rings from UNX (U, n=16; open circles), DOCA-salt (D, n=7; filled circles), DOCA-salt+pirfenidone (DP, n=7; filled triangles) and DOCA-salt+amiloride (DA, n=5; filled squares) treated animals; *P<0.05 compared to UNX, **P<0.05 compared to DOCA-salt.