Figure 7.

Per cent change in heart rate in anaesthetized rabbits during each of the three consecutive dosing cycles. Values are means with vertical bars indicating s.e.mean. Group n values are vehicle=5, clofilium=8, terfenadine=7 and halofantrine=6. At some time points n is less than the total for the group because marked arrhythmic activity prevented accurate measurement of heart rate. Where data are missing n<3 due to arrhythmias or in the case of terfenadine, contractile failure. *P<0.05 compared to vehicle control group, Kruskal-Wallis test.