Figure 3.

Effects of intraplantar co-injection of carrageenan and selective PAR-1 agonists and thrombin on carrageenan-induced inflammatory hyperalgesia (a,b), granulocyte infiltration (c) and oedema (d). The changes in nociceptive threshold and withdrawal latency were calculated for each rat as the area under the curve versus time (over a 6 h period) and results are presented as mean±s.e.mean. For all, n=8 rats per group and for (a and b), *P<0.05 compared to carrageenan alone. No significant differences were observed in all groups for (c) and (d).