Figure 3.
Effects of the PAF receptor antagonist, UK-74,505, and of PAF receptor deficiency on the eosinophil recruitment induced by allergen challenge in sensitized mice. (A) Mice were pretreated with UK-74,505 (1 mg kg−1, i.p.) 60 min before the i.pl. injection of antigen (OVA, 1 μg per cavity) in sensitized mice and the number of infiltrating eosinophils assessed after 48 h. (B) Immunized wild-type or PAFR−/− received an i.pl. injection of antigen (OVA, 1 μg per cavity) and the number of infiltrating eosinophils assessed after 48 h. Results are expressed as means±s.e.mean of six mice in each group. *P<0.01 when compared to PBS-injected mice and #P<0.01 when compared to animals treated with drug vehicle.