Figure 2.

Effects of LY379268, administered at different time points, on inflammatory hyperalgesia. Thermal paw withdrawal latency (PWL) was tested in rats in which LY379268 (3 mg kg⁻¹; circles; n=7 – 9) or vehicle (saline; squares; n=5 – 8) was injected i.p. either 3 h after (A), concurrently with (B), or 1 h before (C), intraplantar carrageenan injection (carr). All values are given as mean±s.e.m. PWL of the paw injected with carrageenan is shown by closed symbols, and the contralateral PWL is shown in A and B by open symbols. Baseline PWL is indicated by a dotted line. In (C) LY379268 is contrasted with its enantiomer LY379267 (3 mg kg⁻¹; diamonds; n=8). *=P<0.05, vehicle vs LY379268, Mann – Whitney test.