Figure 4.

Effects of LY379268, or its inactive enantiomer LY379267, on the development of thermal hyperalgesia induced 1 h after drug. (A): Thermal paw withdrawal latency (PWL) measured in rats 2 h after intraplantar carrageenan injection, shown as a change from pre-carrageenan baseline value; n=6 – 9 per group. **=P<0.01, vehicle vs LY379268 3 mg kg⁻¹ i.p. (B): Tail withdrawal latencies (TWL) in mice 3 min after capsaicin injection into the tail, also expressed as a change from baseline; n=7 – 10 per group. **=P<0.01, vehicle vs LY379268 12 mg kg⁻¹ i.p. All values are mean±s.e.m.