Figure 5.

Upper panel: effect of cyclo-oxygenase inhibitors on release of 6-keto PGF_1α in perfusates of rabbit heart preparations subjected to low-flow ischaemia (1 ml min⁻¹ for 40 min) and reperfusion (20 ml min⁻¹ for 20 min). The data shown are from samples collected during the first 10 min of the reperfusion period. Lower panel: effects of cyclo-oxygenase inhibitors on whole blood thromboxane synthesis in vitro. *P<0.05, **P<0.01, ***P<0.001 versus the vehicle-treated group. The results are expressed as a percentage of the levels of release of these prostanoids in the vehicle-treated group. Each bar represents the mean±s.e.mean of 5 – 10 experiments.