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Effect of La3+, Cd2+, nifedipine or SK&F96365 on thapsigargin-induced CCE. After cells were initially treated with buffer, 100 μM La3+, 100 μM Cd2+, 10 μM nifedipine (NIF) or 10 μM SK&F96365 as indicated, thapsigargin (TG) (1 μM) was then added in each group. Five min after thapsigargin addition, extracellular Ca2+ was removed from and added back to the bathing buffer. [Ca2+]i changes were measured. Similar results were seen using three different batches of cells (n=8).
