Figure 1.

Dose-response curves for the administration of diclofenac (DICLO), neostigmine (NEO) and the simultaneous administration of DICLO+NEO (A: intraperitoneal, B: intrathecal). Isobologram for the simultaneous administration of diclofenac and neostigmine (C: intraperitoneal; D: intrathecal). Filled circles correspond to the theoretical ED₅₀ with 95% confidence limits and open circles correspond to the experimental ED₅₀ with 95% confidence limits. Ordinates of intraperitoneal (i.p.) and intrathecal (i.t.) isobolograms are on different scales.