Figure 6.
The ability of pilocarpine, McN-A343 and carbachol to activate Icat over a broad range of membrane potential. (a) Current traces from three different cells held at −40 mV to which a negative going ramp pulse from 40 to −80 mV over 0.5 s was applied before (open sqaure) and during application (closed square) of 300 μM carbachol (CCh), pilocarpine (Pilo) or McN-A343. (b) Current-voltage (I-V) curves for CCh, Pilo and McN-A343 from the respective cells in (a), which were constructed by subtracting the I-V curve before application of the agonists from that obtained during their application. See text for details.