Figure 7.

Summary of muscarinic agonist potency for cyclic AMP and I_cat responses. The former potency was defined by the per cent inhibition (at 300 μM) of the isoprenaline-stimulated cyclic AMP accumulation (Figure 2) and the latter by the maximum response of I_cat (the I_max in Table 1). These respective potencies were normalized by the value for carbachol. The relative potencies are shown for the cyclic AMP responses in the absence and presence of both 1 μM thapsigargin and 10 μM D600 and for the I_cat response of the indicated individual agonists.