Figure 3.

Effect of T-162559 on changes in the left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure (LVEDP) and lactate dehydrogenase (LDH) release induced by global ischaemia and reperfusion in perfused rat hearts. The time-course of changes in the LVDP and LVEDP before, during and after global ischaemia is shown in the upper panels, and LDH release from the injured heart measured 40 min after reperfusion is shown in the bottom panel. The dotted line between 0 and 10 min in the top panel is an interpolation and does not accurately reflect the time course of changes in LVDP. Values are expressed as means±s.e.mean. n=5. ^*P⩽0.05 and ^**P⩽0.01 versus the vehicle group (Dunnett's test with Bonferroni correction for four time points).