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Calcein apparent permeability (Papp) across mouse intestine. Unidirectional (A-B, B-A) and net permeability of calcein (80 μM) across unstripped ileum from (A) FVB control and (B) mdr1a (−/−) mice (n=6 and 4 tissues in each direction, four and three animals in each group, respectively). Values shown are mean±s.e.mean in the absence of inhibitor and after addition of (A) 200 μM quinidine or (B) 20 μM MK571. *P<0.05 compared with net Papp in absence of inhibitor.
