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. 2002 May;136(2):230–236. doi: 10.1038/sj.bjp.0704686

Figure 4.

Figure 4

Effect of the A2A-adenosine receptor antagonist ZM 241385 and of the A1-adenosine receptor antagonist DPCPX on the evoked tritium overflows from isolated rat tail artery in the absence (solvent; open bars) or in the presence of the α2-adrenoceptor antagonist yohimbine (filled bars). S1 and S2 are the overflows elicited by trains of 100 pulses at 5 Hz (30 min intervals between trains). When indicated, yohimbine (1 μM) was added throughout the superfusion; ZM 241385 or DPCPX were added 20 min before S2. Ordinate, S2/S1 values obtained in individual tissue preparations and expressed as percentage of the corresponding average control S2/S1 value. Values are means±s.e.mean from 8–15 tissue preparations. Significant differences from the effect in the presence of yohimbine: *P<0.05; n.s., non significant (unpaired Student's t-test).