Figure 1.

Changes of mean coronary blood flow (CBF) and coronary diameter (CD) responses to intracoronary acetylcholine (Ach), nitroglycerin (NTG) and adenosine (Ade) before and after induction of heart failure. In heart failure, the coronary responses to acetylcholine and adenosine were impaired while the responses to nitroglycerin were unchanged. *P<0.05 versus corresponding baseline values. P value in each graph is the P value obtained by ANOVA for comparison between the control state and heart failure.