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. 2002 May;136(2):207–216. doi: 10.1038/sj.bjp.0704703

Figure 9.

Figure 9

Effects of tramadol on nicotinic receptor-stimulated currents in Xenopus oocytes expressing α7 receptors. (A) Tracings obtained from a single oocyte expressing α7 nicotinic AChRs show the effect of tramadol on 1 mM nicotine-induced currents. Nicotine was applied for 20 s with or without 2 min treatment with 10 μM tramadol. (B) Concentration-response relationship of tramadol on nicotine-induced currents. Tramadol (100 nM–100 μM) was applied to the oocytes for 2 min and then 1 mM nicotine was applied for 20 s. Data represent the mean±s.e.mean (n=3–6). ***P<0.001 compared with the control response, using ANOVA.