Figure 7.

Dose-related inhibition of gastric emptying of a solid meal by intracisternal injection of urocortin in conscious fed rats (a) and blockade of urocortin effects by pretreatment with the selective CRF₂ receptor antagonist astressin₂-B (b). Fasted rats were given free access to Purina chow and water for 3 h, then food and water were removed; (a) saline or rUcn (0.3–1 μg) was injected i.c. in different groups of rats; (b) vehicle or astressin₂-B was injected i.c. followed by i.c. injection of saline or rUcn (1 μg) and gastric emptying monitored 5 h later. Each bar represents the mean±s.e.m.; the number of rats per group is indicated on top of each bar. *P<0.05 compared with vehicle (0.0) and rUen (0.3). #P<0.05 compared with other experimental groups.