Figure 4.
Effect of 5-HT, 5-CT, 2-Me-5-HT, 5-MeOT and α-Me-5-HT on the PGF2α-induced contraction of canine proximal stomach longitudinal muscle preparation. The curves to 5-CT, α-Me-5-HT and 5-MeOT represent simulations using the Hill equation; the parameters for α (shown in vertical error bars) and EC50 (shown with horizontal error bars) were obtained from the iterative fitting procedure. The vertically averaged data points of 5-HT and 2-Me-5-HT are connected. The responses are expressed as percentage of muscle strip contraction to KCl (0.16 M).