Figure 3.

Urethane anaesthetized female rats: traces showing reflex-evoked isovolumetric (i.e. occurring when intravesical infusion of saline to evoke the reflex had been stopped; see Figure 2) changes in bladder and urethral pressures before (control) and after i.v. injections of (A) saline, (B) L-NAME, 20 mg kg⁻¹ and an infusion of (C) zaprinast, 0.6 mg kg⁻¹ min⁻¹. It should be noted that the saline vehicle trace (A) is also representative of the effects of zaprinast vehicle (5% triethanolamine in saline), which has not shown for the sake of clarity. Shaded bars represent duration of intravesical infusions of saline to evoke the micturition reflex.