Figure 5.

Urethane anaesthetized α-bungarotoxin (0.4 mg kg⁻¹, i.v.) pre-treated female rats: traces showing reflex-evoked isovolumetric (i.e. occurring when intravesical infusion of saline to evoke the reflex had been stopped; see Figure 2) changes in bladder and urethral pressures before (control) and after i.v. injections of (A) saline, (B) 20 mg kg⁻¹ of L-NAME and infusion of (C) 0.6 mg kg⁻¹ min⁻¹ of zaprinast. Saline vehicle trace (A) is also representative of the effects of zaprinast vehicle (5% triethanolamine in saline), which is not shown for the sake of clarity.