Figure 7.

Urethane anaesthetized female rats: a comparison of the effects of i.u. perfusion (0.075 ml min⁻¹) of vehicle (saline) and zaprinast (1 mM) for 60 min in the absence and presence of pre-treatment with chlorisondamine (10 mg kg⁻¹, i.v.) on percentage changes (Δ) in (A) baseline urethral pressure and (B) integrated urethral striated muscle activity (EUS-EMG). Each point represents the mean value and vertical bars show s.e.mean. Changes caused by zaprinast were compared with the appropriate controls using two-way analysis of variance followed by the least significance difference test. ^*P<0.05 ^**P<0.01.