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. 2002 Jun;136(4):510–519. doi: 10.1038/sj.bjp.0704747

Figure 6.

Figure 6

2C-N is a competitive antagonist at the 5-HT2A receptor. (A) The co-application of different concentrations of 2C-N plus 100 nM 5-HT blocked the 5-HT-induced currents in a concentration-dependent manner; the sole application of 2C-N did not elicit responses (n=5–6). (B) The inhibition of the 100 nM 5-HT-induced currents by 50 nM 2C-N was time-independent (n=4). (C) Rightward displacements of the control 5-HT concentration-response curve by the co-application of 5-HT plus 0.04 μM (n=4); 1 μM (n=4) or 10 μM 2C-N (n=2). The insert shows a Schild plot. Symbols represent mean values; bars, s.e.mean.