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. 2002 Jul;136(5):773–783. doi: 10.1038/sj.bjp.0704778

Figure 4.

Figure 4

Pharmacological effects of BAY 58-2667 in vitro. (A) Inhibition of phenylephrine (30 μg ml−1) induced contractions of isolated rabbit saphenous arteries by BAY 58-2667, BAY 41-2272, SNP and SIN-1. Values are means±s.e.mean of six, 16, eight and seven experiments. (B) Effects of BAY 58-2667 and GTN on phenylephrine-induced contractions of isolated rabbit saphenous arteries from normal and tolerant rabbits. Values are means±s.e.mean of eight and 11 vessels. *P<0.05 and ** P<0.01 vs normal saphenous artery rings. (C) Effect of BAY 58-2667 and GTN on coronary perfusion pressure at the rat heart Langendorff preparation. (D) The inhibitory effects of BAY 58-2667 on U 46619, collagen, ADP, TRAP-6-induced platelet aggregation in human platelet rich plasma and on thrombin-induced platelet aggregation in washed human platelets. The final concentrations of U 46619, collagen, ADP, TRAP-6 and thrombin were 1, 1 – 2, 30 – 50, and 5 μg ml−1, respectively. The effects were expressed as percentage inhibition of platelet aggregation compared to vehicle control. Each value represents the mean±s.e.mean from eight (U46619), 14 (collagen), five (ADP), five (TRAP-6), four (thrombin) experiments.