Figure 1.

α4β2 ion channel models. Views of the normal (a, c) and mutant (b, d) receptors are extracellular and perpendicular to the membrane plane. Transmembrane segments M2 are schematically represented by violet ribbons. Black dots represent the solvent accessible surface within the ion-channel. (a, c) Side chains of the two α4 Ser 248 (upper and lower) and β2′′ Ser 271 (right) residues are shown in stick representation. Colour coding is atom based (C: green; H: white; N: blue; O: red). (b, d) Side chains of the two α4 Phe 248 (upper and lower) and β2′′ Ser 271 (right) residues are shown in stick representation. Colour coding as before. (c, d) The best ranked CBZ conformers in their docked conformations are displayed in these panels in stick representation. Colour coding as before. Their solvent accessible surface is also represented by dense black dots.